Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti-dengue treatment: A review.
J Med Virol
; 92(8): 941-955, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-31784997
ABSTRACT
Dengue virus is an arbovirus belonging to class Flaviviridae Its clinical manifestation ranges from asymptomatic to extreme conditions (dengue hemorrhagic fever/dengue shock syndrome). A lot of research has been done on this ailment, yet there is no effective treatment available for the disease. This review provides the systematic understanding of all dengue proteins, role of its structural proteins (C-protein, E-protein, prM) in virus entry, assembly, and secretion in host cell, and nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5) in viral assembly, replication, and immune evasion during dengue progression and pathogenesis. Furthermore, the review has highlighted the controversies related to the only commercially available dengue vaccine, that is, Dengvaxia, and the risk associated with it. Lastly, it provides an insight regarding various approaches for developing an effective anti-dengue treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Proteínas Estruturais Virais
/
Proteínas não Estruturais Virais
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Dengue
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Vírus da Dengue
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Vacinas contra Dengue
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Paquistão
País de publicação:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA