Your browser doesn't support javascript.
loading
C-reactive protein level predicts 30-day mortality and bleeding in patients with venous thromboembolism: A prospective single-center study.
Demelo-Rodríguez, Pablo; Galeano-Valle, Francisco; Marcelo-Ayala, Almudena; Fernández-Carracedo, Eduardo; Cuenca-Zarzuela, Alicia; Gómez-Morales, Marina; Alvarez-Sala-Walther, Luis Antonio; Bellón-Cano, José María; Del-Toro-Cervera, Jorge.
Afiliação
  • Demelo-Rodríguez P; Venous Thromboembolism Unit, Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón, Madrid, Spain.
  • Galeano-Valle F; Venous Thromboembolism Unit, Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón, Madrid, Spain. Electronic address: paco.galeano
  • Marcelo-Ayala A; Venous Thromboembolism Unit, Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Fernández-Carracedo E; Venous Thromboembolism Unit, Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Cuenca-Zarzuela A; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain.
  • Gómez-Morales M; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain.
  • Alvarez-Sala-Walther LA; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón, Madrid, Spain.
  • Bellón-Cano JM; Department of Statistics, Instituto de investigación Sanitaria Gregorio Marañón, Madrid, Spain.
  • Del-Toro-Cervera J; Venous Thromboembolism Unit, Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Med Clin (Barc) ; 155(2): 51-56, 2020 07 24.
Article em En, Es | MEDLINE | ID: mdl-31787321
ABSTRACT

AIMS:

The association of on-admission CRP and early adverse outcomes in acute venous thromboembolism (VTE) has not been investigated. We hypothesized that increased on-admission CRP levels would correlate with adverse outcomes in patients with acute VTE.

METHOD:

In this prospective observational study, consecutive patients with acute VTE were enrolled and CRP levels were measured within the first 24h after diagnosis. Mortality, bleeding and recurrence were recorded during a 30-day follow-up.

RESULTS:

586 patients were included. Higher CRP levels were found in patients with mortality (7.5 vs 4.0mg/dL; p=0.01) and bleeding (7.8 vs 3.9mg/dL; p=0.03). Multivariable logistic regression showed that CRP levels >5mg/dL were associated with higher mortality (OR 6.25; 95% CI, 2.1-18.6) and bleeding (OR 2.7; CI 95% 1.3-5.7). These results were independent to ESC risk score and simplified PESI score for mortality prediction. The predictive capacity of CRP showed an area under the ROC curve - AUC - of .7 (CI 95% .56-.85) for mortality and .65 (CI 95% .54-.75) for bleeding. The prognostic capacity of the ESC risk score and simplified PESI score was improved after adding the CRP cutoff of 5mg/dL (AUC of .87 CI 95% .79-.95).

CONCLUSION:

Our findings suggest that on-admission CRP level may be a simple, widely available and valuable biomarker to identify high-risk VTE patients for early mortality and bleeding. CRP ≥5mg/dL was independently associated with 30-day VTE related death and bleeding.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose Venosa / Tromboembolia Venosa Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En / Es Revista: Med Clin (Barc) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: ES / ESPANHA / ESPAÑA / SPAIN

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose Venosa / Tromboembolia Venosa Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En / Es Revista: Med Clin (Barc) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha País de publicação: ES / ESPANHA / ESPAÑA / SPAIN