The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.

Wu, Shidi; Zhao, Mengjie; Sun, Yanhong; Xie, Meng; Le, Kehao; Xu, Ming; Huang, Changzheng

Wu, Shidi; Zhao, Mengjie; Sun, Yanhong; Xie, Meng; Le, Kehao; Xu, Ming; Huang, Changzheng.

Afiliação

Wu S; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China.
Zhao M; Department of Dermatology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430022, Hubei, PR China.
Sun Y; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China.
Xie M; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China.
Le K; Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China.
Xu M; Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China.
Huang C; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. Electronic address: hcz0501@126.com.

Life Sci ; 241: 117115, 2020 Jan 15.

Article em En | MEDLINE | ID: mdl-31790685

Assuntos

Diosgenina/farmacologia; Queratinócitos/efeitos dos fármacos; Psoríase/tratamento farmacológico; Inibidores da Angiogênese/farmacologia; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Citocinas/sangue; Diosgenina/efeitos adversos; Modelos Animais de Doenças; Feminino; Células Endoteliais da Veia Umbilical Humana; Humanos; Imiquimode/toxicidade; Queratinócitos/metabolismo; Queratinócitos/patologia; Camundongos Endogâmicos BALB C; NF-kappa B/metabolismo; Psoríase/induzido quimicamente; Psoríase/patologia; Receptores de Interleucina/metabolismo

Palavras-chave

Cytokines; Differentiation; Diosgenin; HMEC-1; HUVECs; HaCaT cells; Imiquimod; Proliferation; Psoriasis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Queratinócitos / Diosgenina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google