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Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates.
Kowalski, John P; McDonald, Matthew G; Whittington, Dale; Guttman, Miklos; Scian, Michele; Girhard, Marco; Hanenberg, Helmut; Wiek, Constanze; Rettie, Allan E.
Afiliação
  • Kowalski JP; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
  • McDonald MG; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
  • Whittington D; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
  • Guttman M; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
  • Scian M; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
  • Girhard M; Institute of Biochemistry , Heinrich-Heine University , 40225 Düsseldorf , Germany.
  • Hanenberg H; Department of Pediatrics III, University Children's Hospital Essen , University of Duisburg-Essen , 45122 Essen , Germany.
  • Wiek C; Department of Otorhinolaryngology and Head/Neck Surgery , Heinrich-Heine University , 40225 Düsseldorf , Germany.
  • Rettie AE; Department of Medicinal Chemistry, School of Pharmacy , University of Washington , Seattle , Washington 98105 , United States.
Chem Res Toxicol ; 32(12): 2488-2498, 2019 12 16.
Article em En | MEDLINE | ID: mdl-31799839
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrocarboneto de Aril Hidroxilases / Furanos / Amidas Limite: Animals / Humans Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrocarboneto de Aril Hidroxilases / Furanos / Amidas Limite: Animals / Humans Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos