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Analysis of CASP12 diagnostic and prognostic values in cervical cancer based on TCGA database.
Feng, Guo; Beilei, Zhang; Caizhi, Chen; Wen, Zou.
Afiliação
  • Feng G; Department of Oncology of the Second Xiangya Hospital of Central South University, Changsha, China.
  • Beilei Z; Department of Gynecology of Hunan Provincial Cancer Hospital of Central South University, Changsha, China.
  • Caizhi C; Department of Oncology of the Second Xiangya Hospital of Central South University, Changsha, China.
  • Wen Z; Department of Oncology of the Second Xiangya Hospital of Central South University, Changsha, China.
Biosci Rep ; 39(12)2019 12 20.
Article em En | MEDLINE | ID: mdl-31804677
ABSTRACT
The present study aims to find a differential protein-coding gene caspase 12 (CASP12) in cervical cancer (CC) based on the (TCGA) database and verify its clinical diagnostic and prognostic values. The transcriptome and clinicopathological data of CC were downloaded from the TCGA database and through screening, we found that PDE2A and CASP12 were independent prognostic factors for CC patients. According to the median expression, the patients were divided into groups with high and low CASP12 and PDE2A expression. There was no difference in survival between PDE2A high and low expression groups (P=0.099), whereas there was a significant difference between CASP12 high and low expression groups (P=0.033). The serum from 68 CC patients (experimental group) and 50 healthy people (control group) was collected to detect the relative expression of CASP12 using qRT-PCR and plotted the ROC curve. The relative expression of CASP12 in the experimental group was significantly lower than in the control group (P<0.05). The area under the curve (AUC) of CASP12 was 0.865. There were statistically significant differences between CASP12 groups with high and low expression in terms of differentiation, lymph node metastasis, tumor size, FIGO staging, and clinical outcomes (P<0.05), but not in terms of age, HPV types and pathological types (P>0.05). The 3-year survival in the CASP12 low expression group was significantly worse than in the CASP12 high expression group (P=0.028). In conclusion, the expression level of CASP12 can be used as a diagnostic and prognostic biomarker for patients with CC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Regulação Neoplásica da Expressão Gênica / Neoplasias do Colo do Útero / Bases de Dados de Ácidos Nucleicos / Caspase 12 / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Biosci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Regulação Neoplásica da Expressão Gênica / Neoplasias do Colo do Útero / Bases de Dados de Ácidos Nucleicos / Caspase 12 / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Biosci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China