HMGB1 upregulates NF-kB by inhibiting IKB-&#945; and associates with diabetic retinopathy.

Liang, Wen-Jing; Yang, Hong-Wei; Liu, He-Nan; Qian, Wei; Chen, Xiao-Long

HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy.

Liang, Wen-Jing; Yang, Hong-Wei; Liu, He-Nan; Qian, Wei; Chen, Xiao-Long.

Afiliação

Liang WJ; Department of Ophthalmology, Shengjing Hospital, China Medical University, No.36 Sanhao Street, Heping District Shenyang, Liaoning Zip, China. Electronic address: 1611220453@qq.com.
Yang HW; Department of Ophthalmology, Shengjing Hospital, China Medical University, No.36 Sanhao Street, Heping District Shenyang, Liaoning Zip, China. Electronic address: yanghw@sj-hospital.org.
Liu HN; Department of Ophthalmology, Shengjing Hospital, China Medical University, No.36 Sanhao Street, Heping District Shenyang, Liaoning Zip, China. Electronic address: liuhn@sj-hospital.org.
Qian W; Medical Imaging Informatics Laboratory College of Engineering, University of Texas, El Paso 500 West University Avenue El Paso, TX 79968, United States of America. Electronic address: wqian@utep.edu.
Chen XL; Department of Ophthalmology, Shengjing Hospital, China Medical University, No.36 Sanhao Street, Heping District Shenyang, Liaoning Zip, China. Electronic address: chenxiaolongsj@163.com.

Life Sci ; 241: 117146, 2020 Jan 15.

Article em En | MEDLINE | ID: mdl-31816325

Assuntos

Diabetes Mellitus Experimental/complicações; Retinopatia Diabética/patologia; Modelos Animais de Doenças; Regulação da Expressão Gênica; Proteína HMGB1/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; NF-kappa B/metabolismo; Animais; Apoptose; Proliferação de Células; Células Cultivadas; Retinopatia Diabética/etiologia; Retinopatia Diabética/metabolismo; Células Endoteliais/citologia; Células Endoteliais/metabolismo; Proteína HMGB1/genética; Humanos; Masculino; Inibidor de NF-kappaB alfa/genética; NF-kappa B/genética; Ratos; Ratos Sprague-Dawley; Retina/citologia; Retina/metabolismo

Palavras-chave

Chip-seq; Diabetic retinopathy; HMGB1; NF-kB

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / NF-kappa B / Proteína HMGB1 / Diabetes Mellitus Experimental / Retinopatia Diabética / Modelos Animais de Doenças / Inibidor de NF-kappaB alfa Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

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