Nitrogen-doped carbon quantum dots embedded Co3O4 with multiwall carbon nanotubes: An efficient probe for the simultaneous determination of anticancer and antibiotic drugs.
Biosens Bioelectron
; 150: 111947, 2020 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-31818763
ABSTRACT
The simultaneous determination of anticancer and antibiotic drugs in biological samples with fast and sensitive methods is an essential task for the effective monitoring of drug therapy. A novel electrochemical sensor for the simultaneous determination of anticancer drug Flutamide (FLU) and antibiotic drug Nitrofurantoin (NF) was developed based on the glassy carbon electrode (GCE) modified with N-CQD@Co3O4/MWCNTs hybrid nanocomposite. The electro-kinetics of the developed sensor was studied using cyclic voltammetry (CV). The electrochemical performance of FLU and NF on the N-CQD@Co3O4/MWCNTs/GCE surface was examined using CV and differential pulse voltammetry (DPV) techniques. At an optimized condition, the developed sensor exhibits excellent performance in simultaneous determination of FLU and NF with a linear range of 0.05-590 µM and 0.05-1220 µM and detection limit of 0.0169 µM and 0.044 µM respectively. Furthermore, the developed sensor exhibits satisfactory results in the real sample analysis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óxidos
/
Cobalto
/
Nanotubos de Carbono
/
Pontos Quânticos
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Antibacterianos
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Antineoplásicos
/
Nitrogênio
Limite:
Humans
Idioma:
En
Revista:
Biosens Bioelectron
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia