Nitrogen-doped carbon quantum dots embedded Co3O4 with multiwall carbon nanotubes: An efficient probe for the simultaneous determination of anticancer and antibiotic drugs.

ABSTRACT

The simultaneous determination of anticancer and antibiotic drugs in biological samples with fast and sensitive methods is an essential task for the effective monitoring of drug therapy. A novel electrochemical sensor for the simultaneous determination of anticancer drug Flutamide (FLU) and antibiotic drug Nitrofurantoin (NF) was developed based on the glassy carbon electrode (GCE) modified with N-CQD@Co3O4/MWCNTs hybrid nanocomposite. The electro-kinetics of the developed sensor was studied using cyclic voltammetry (CV). The electrochemical performance of FLU and NF on the N-CQD@Co3O4/MWCNTs/GCE surface was examined using CV and differential pulse voltammetry (DPV) techniques. At an optimized condition, the developed sensor exhibits excellent performance in simultaneous determination of FLU and NF with a linear range of 0.05-590 µM and 0.05-1220 µM and detection limit of 0.0169 µM and 0.044 µM respectively. Furthermore, the developed sensor exhibits satisfactory results in the real sample analysis.