Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations.

Pashirova, T N; Sapunova, A S; Lukashenko, S S; Burilova, E A; Lubina, A P; Shaihutdinova, Z M; Gerasimova, T P; Kovalenko, V I; Voloshina, A D; Souto, E B; Zakharova, L Ya

Pashirova, T N; Sapunova, A S; Lukashenko, S S; Burilova, E A; Lubina, A P; Shaihutdinova, Z M; Gerasimova, T P; Kovalenko, V I; Voloshina, A D; Souto, E B; Zakharova, L Ya.

Afiliação

Pashirova TN; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia. Electronic address: tatyana_pashirova@mail.ru.
Sapunova AS; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Lukashenko SS; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Burilova EA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Lubina AP; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Shaihutdinova ZM; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Gerasimova TP; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Kovalenko VI; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Voloshina AD; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.
Souto EB; Department of Pharmaceutical Terchnology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Zakharova LY; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Arbuzov St., 8, Kazan 420088, Russia.

Int J Pharm ; 575: 118953, 2020 Feb 15.

Article em En | MEDLINE | ID: mdl-31843548

Assuntos

Antibacterianos/farmacologia; Lipossomos/farmacologia; Piperazinas/química; Piperazinas/farmacologia; Tecnologia Farmacêutica/métodos; Administração Cutânea; Antibacterianos/farmacocinética; Compostos Aza/química; Proteínas da Membrana Bacteriana Externa; Linhagem Celular; Sobrevivência Celular; Ciclo-Octanos/química; Relação Dose-Resposta a Droga; Fungos/efeitos dos fármacos; Bactérias Gram-Negativas/efeitos dos fármacos; Bactérias Gram-Positivas/efeitos dos fármacos; Humanos; Interações Hidrofóbicas e Hidrofílicas; Lipossomos/química; Lipossomos/farmacocinética; Micelas; Testes de Sensibilidade Microbiana; Tamanho da Partícula; Piperazinas/síntese química; Piperazinas/farmacocinética; Pele/efeitos dos fármacos; Relação Estrutura-Atividade; Tensoativos/química; Tensoativos/farmacologia

Palavras-chave

Antimicrobial activity; Cationic surfactants; Liposomes; Quaternary ammonium derivatives of 1,4-diazabicyclo[2.2.2]octane; Skin permeation; Solubilization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Tecnologia Farmacêutica / Lipossomos / Antibacterianos Limite: Humans Idioma: En Revista: Int J Pharm Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

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