Risk Factors for Hen's Egg Allergy in Europe: EuroPrevall Birth Cohort.
J Allergy Clin Immunol Pract
; 8(4): 1341-1348.e5, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31846795
ABSTRACT
BACKGROUND:
Hen's egg is one of the commonest causes of food allergy, but there are little data on its risk factors.OBJECTIVE:
To assess the risk factors, particularly eczema, for hen's egg allergy in the EuroPrevall birth cohort.METHODS:
In the pan-European EuroPrevall birth cohort, questionnaires were undertaken at 12 and 24 months or when parents reported symptoms. Children with suspected egg allergy were invited for skin prick testing, specific IgE assessment, and double-blind, placebo-controlled food challenge (DBPCFC) as indicated. Each egg allergy case (positive DBPCFC or egg-induced anaphylaxis) was allocated up to 2 age- and country-matched controls.RESULTS:
A total of 12,049 infants were recruited into the EuroPrevall birth cohort, and 9,336 (77.5%) were followed until 2 years. A total of 86 infants had egg allergy (84 by DBPCFC) and were matched with 140 controls. Independently associated with egg allergy were past/current eczema (adjusted odds ratio, 9.21; 95% CI, 2.65-32.04), Scoring Atopic Dermatitis (1.54 per 5 units; 1.28-1.86), antibiotics in the first week of life (6.17; 1.42-26.89), and current rhinitis (3.02; 1.04-8.78). Increasing eczema severity was associated with an increasing likelihood of egg allergy. Eczema was reported to have started 3.6 (SE, 0.5) months before egg allergy. Age of introduction of egg into the diet was not associated with egg allergy.CONCLUSIONS:
Similar to peanut allergy, eczema was strongly associated with egg allergy development and the association increased with increasing eczema severity. The age of introduction of dietary egg was not a risk factor. The potential role of antibiotics in early life as a risk factor for egg allergy needs further examination.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade a Ovo
/
Hipersensibilidade Alimentar
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Child, preschool
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Female
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Humans
/
Infant
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Allergy Clin Immunol Pract
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido