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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.
Gassen, Nils C; Niemeyer, Daniela; Muth, Doreen; Corman, Victor M; Martinelli, Silvia; Gassen, Alwine; Hafner, Kathrin; Papies, Jan; Mösbauer, Kirstin; Zellner, Andreas; Zannas, Anthony S; Herrmann, Alexander; Holsboer, Florian; Brack-Werner, Ruth; Boshart, Michael; Müller-Myhsok, Bertram; Drosten, Christian; Müller, Marcel A; Rein, Theo.
Afiliação
  • Gassen NC; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany. ncgassen@psych.mpg.de.
  • Niemeyer D; Department of Psychiatry and Psychotherapy, University of Bonn, Venusberg Campus 1, 53127, Bonn, Germany. ncgassen@psych.mpg.de.
  • Muth D; Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
  • Corman VM; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Martinelli S; Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
  • Gassen A; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Hafner K; Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
  • Papies J; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Mösbauer K; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany.
  • Zellner A; Faculty of Biology, Genetics, Ludwig-Maximilian-University Munich (LMU), 82152, Martinsried, Germany.
  • Zannas AS; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany.
  • Herrmann A; Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
  • Holsboer F; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Brack-Werner R; Institute of Virology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
  • Boshart M; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany.
  • Drosten C; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany.
  • Müller MA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27710, USA.
  • Rein T; Department of Psychiatry, University of North Carolina at Chapel Hill, 438 Taylor Hall, 109 Mason Farm Road, Chapel Hill, 27599-7096, NC, USA.
Nat Commun ; 10(1): 5770, 2019 12 18.
Article em En | MEDLINE | ID: mdl-31852899
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Infecções por Coronavirus / Proteínas Quinases Associadas a Fase S / Coronavírus da Síndrome Respiratória do Oriente Médio / Proteína Beclina-1 Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Infecções por Coronavirus / Proteínas Quinases Associadas a Fase S / Coronavírus da Síndrome Respiratória do Oriente Médio / Proteína Beclina-1 Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido