Determinants of Low Body Mass Index in Patients with Parkinson's Disease: A Multicenter Case-Control Study.
J Parkinsons Dis
; 10(1): 213-221, 2020.
Article
em En
| MEDLINE
| ID: mdl-31868678
ABSTRACT
BACKGROUND:
In Parkinson's disease (PD) patients, the factors related to weight loss remain unclear.OBJECTIVE:
To investigate determinants of low body mass index (BMI) in PD patients.METHODS:
We identified factors associated with low BMI in PD patients in a multicenter case-control study. A total of 435 PD patients and 401 controls were included.RESULTS:
The mean BMI was significantly lower in PD patients than in controls (22.0±3.4âkg/m2 vs. 25.4±4.3âkg/m2), with an adjusted odds ratio (AOR) of 3.072 (95% CI, 2.103-4.488; pâ<â0.001) for low BMI (<22âkg/m2) in PD. Compared to the high-BMI PD group (>22âkg/m2), the low-BMI PD group (<22âkg/m2) had more women; a longer disease duration; higher revised Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) II and IV scores; an increased levodopa equivalent dose (LED); and increased constipation, visual hallucination, dysphagia, dyskinesia and wearing off rates. There were no between-group differences in depression, anhedonia, apathy, sleep problems and daytime sleepiness. Multivariable analysis showed that visual hallucination (AOR, 2.408; 95% CI, 1.074-5.399; pâ=â0.033) and the MDS-UPDRS IV (AOR, 1.155; 95% CI, 1.058-1.260; pâ=â0.001) contributed to low BMI after controlling for clinical factors. In a second model, visual hallucination (AOR, 2.481; 95% CI, 1.104-5.576; pâ=â0.028) and dyskinesia (sum of the MDS-UPDRS 4.3-4.6) (AOR, 1.319; 95% CI, 1.043-1.668; pâ=â0.021) significantly contributed to low BMI.CONCLUSION:
PD patients were 3 times more likely than healthy controls to have a low BMI. Motor complications, particularly dyskinesia, and visual hallucination were significantly associated with low BMI in PD patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Dopaminérgicos
/
Levodopa
/
Índice de Massa Corporal
/
Discinesias
/
Alucinações
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Parkinsons Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão