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The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model.
Tijchon, Esther; Yi, Guoqiang; Mandoli, Amit; Smits, Jos G A; Ferrari, Francesco; Heuts, Branco M H; Wijnen, Falco; Kim, Bowon; Janssen-Megens, Eva M; Schuringa, Jan Jacob; Martens, Joost H A.
Afiliação
  • Tijchon E; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Yi G; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Mandoli A; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Smits JGA; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Ferrari F; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Heuts BMH; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Wijnen F; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Kim B; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Janssen-Megens EM; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
  • Schuringa JJ; Department of Hematology, University Medical Centre Groningen, Groningen, The Netherlands.
  • Martens JHA; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
PLoS One ; 14(12): e0226435, 2019.
Article em En | MEDLINE | ID: mdl-31869378
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Diferenciação Celular / Transformação Celular Neoplásica / Subunidade alfa 2 de Fator de Ligação ao Core / Células-Tronco Pluripotentes Induzidas / Transcriptoma / Proteína 1 Parceira de Translocação de RUNX1 / Granulócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Diferenciação Celular / Transformação Celular Neoplásica / Subunidade alfa 2 de Fator de Ligação ao Core / Células-Tronco Pluripotentes Induzidas / Transcriptoma / Proteína 1 Parceira de Translocação de RUNX1 / Granulócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda