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Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors.
Zhang, Binliang; Zhang, Qian; Xiao, Zhen; Sun, Xin; Yang, Zunhua; Gu, Qi; Liu, Ziqin; Xie, Ting; Jin, Qingqing; Zheng, Pengwu; Xu, Shan; Zhu, Wufu.
Afiliação
  • Zhang B; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Zhang Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Xiao Z; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Sun X; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Yang Z; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
  • Gu Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Liu Z; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Xie T; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Jin Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Zheng P; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
  • Xu S; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China. Electronic address: shanxu9891@126.com.
  • Zhu W; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China. Electronic address: zhuwufu-1122@163.com.
Bioorg Chem ; 95: 103525, 2020 01.
Article em En | MEDLINE | ID: mdl-31887474

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Triazinas / Desenho de Fármacos / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Triazinas / Desenho de Fármacos / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos