Screening for obesity in the offspring of first-cousin consanguineous couples: A Phase-I study in Saudi Arabia.
Saudi J Biol Sci
; 27(1): 242-246, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31889843
ABSTRACT
Consanguineous or cousin marriages are very common in Saudi Arabia. However, owing to limited studies and insufficient knowledge about genetic diseases/disorders, many couples are unaware of the increased health risks for their offspring. Among the inherited and complex diseases from parents' consanguinity, obesity is common; therefore, we examined the prevalence of obesity in the offspring of first-cousin consanguineous couples in Saudi Arabia. In this questionnaire-based study, 657 individuals (mean ageâ¯=â¯18.7⯱â¯10.2â¯years; age rangeâ¯=â¯2-65â¯years) who were residing in Riyadh, Saudi Arabia participated. Among them, almost 90% were native Saudis. Participants mean body mass index (BMI) was 24.5⯱â¯9.1â¯kg/m2. Sex- stratified demographic details confirmed a significant association between age and BMI (pâ¯<â¯.001). We confirmed that adolescents and adults were more prone to develop obesity. Adults and non-Saudi participants were three times more likely to develop obesity if they had first-cousin consanguineous parents than those who did not. Of the 30% of participants who were obese, 100 will be selected for Phase II, in which we plan to perform exome sequencing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
/
Screening_studies
Idioma:
En
Revista:
Saudi J Biol Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Arábia Saudita