Non-enzymatic glycation of human serum albumin modulates its binding efficacy towards bioactive flavonoid chrysin: A detailed study using multi-spectroscopic and computational methods.

Sarmah, Sharat; Pahari, Somdev; Das, Sourav; Belwal, Vinay Kumar; Jana, Madhurima; Singha Roy, Atanu

Sarmah, Sharat; Pahari, Somdev; Das, Sourav; Belwal, Vinay Kumar; Jana, Madhurima; Singha Roy, Atanu.

Afiliação

Sarmah S; Department of Chemistry, National Institute of Technology, Meghalaya, Shillong, India.
Pahari S; Molecular Simulation Laboratory, Department of Chemistry, National Institute of Technology, Rourkela, India.
Das S; Department of Chemistry, National Institute of Technology, Meghalaya, Shillong, India.
Belwal VK; Department of Bioscience and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India.
Jana M; Molecular Simulation Laboratory, Department of Chemistry, National Institute of Technology, Rourkela, India.
Singha Roy A; Department of Chemistry, National Institute of Technology, Meghalaya, Shillong, India.

J Biomol Struct Dyn ; 39(2): 476-492, 2021 Feb.

Article em En | MEDLINE | ID: mdl-31900044

Assuntos

Flavonoides; Albumina Sérica Humana; Sítios de Ligação; Dicroísmo Circular; Humanos; Simulação de Acoplamento Molecular; Ligação Proteica; Albumina Sérica Humana/metabolismo; Espectrometria de Fluorescência; Termodinâmica

Palavras-chave

Human serum albumin; Molecular Dynamics simulation; binding constant; glycation; molecular docking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Albumina Sérica Humana Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido

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