Untangling human neurogenesis to understand and counteract brain disorders.
Curr Opin Pharmacol
; 50: 67-73, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31901615
ABSTRACT
Neurogenesis in the human postnatal brain occurs in two regions, the subventricular zone of the later ventricle and the dentate gyrus of the hippocampus. While it is well accepted that SVZ and hippocampal neurogenesis are active during juvenile stages in human, their contribution during adulthood and ageing as well as pathological states is recently animating the neural stem cell research field. In this review we will discuss recent evidence about the organization of SVZ and hippocampal neurogenic niches, and will report on how human adult neurogenesis may contribute to disease and appears to respond to neurodegeneration. In light of these novel findings, we will discuss how we can target human adult neurogenesis in order to influence brain disease trajectories.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Neurogênese
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article