Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.

Zhao, Pei; Zhou, Wenjing; Zhang, Yanxia; Li, Jingjing; Zhao, Ye; Pan, Lihua; Shen, Zhenya; Chen, Weiqian; Hui, Jie

Zhao, Pei; Zhou, Wenjing; Zhang, Yanxia; Li, Jingjing; Zhao, Ye; Pan, Lihua; Shen, Zhenya; Chen, Weiqian; Hui, Jie.

Afiliação

Zhao P; Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University & Institute for Cardiovascular Science, Soochow University, Suzhou, China.
Zhou W; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhang Y; Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou, China.
Li J; Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University & Institute for Cardiovascular Science, Soochow University, Suzhou, China.
Zhao Y; Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University & Institute for Cardiovascular Science, Soochow University, Suzhou, China.
Pan L; Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University & Institute for Cardiovascular Science, Soochow University, Suzhou, China.
Shen Z; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chen W; Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University & Institute for Cardiovascular Science, Soochow University, Suzhou, China.
Hui J; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

J Cell Mol Med ; 24(4): 2593-2609, 2020 02.

Article em En | MEDLINE | ID: mdl-31930778

Assuntos

Ácido Amino-Oxiacético/farmacologia; Cardiopatias/tratamento farmacológico; Coração/efeitos dos fármacos; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Caspase 1/metabolismo; Cardiopatias/metabolismo; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Infarto do Miocárdio/tratamento farmacológico; Infarto do Miocárdio/metabolismo; Miocárdio/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Remodelação Ventricular/efeitos dos fármacos

Palavras-chave

NLRP3; aminooxyacetic acid; macrophage polarization; metabolic reprogramming; myocardial infarction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Amino-Oxiacético / Coração / Cardiopatias / Macrófagos Limite: Animals Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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