SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation.
Chem Commun (Camb)
; 56(12): 1780-1783, 2020 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-31938791
ABSTRACT
Herein, we disclose the first set of unique selenium-containing SnAP reagents for the direct synthesis of C-substituted selenomorpholines and 1,4-selenazepanes, including their amino acid derivatives from commercially available aldehydes under mild conditions. These elusive N-unprotected heterocycles are not accessible by classical routes. Biological evaluation of these compounds revealed promising activities against clinically relevant fungal strains.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Compostos de Selênio
/
Candida parapsilosis
/
Antifúngicos
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article