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WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Wang, Feng; Zhang, Jiayi; Ke, Xiaoxue; Peng, Wen; Zhao, Gaichao; Peng, Shihan; Xu, Jie; Xu, Bo; Cui, Hongjuan.
Afiliação
  • Wang F; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Zhang J; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Ke X; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Peng W; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Zhao G; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Peng S; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Xu J; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China.
  • Xu B; School Hospital of Southwest University, Southwest University, Beibei, Chongqing, 400716, China.
  • Cui H; State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, 400716, China. Electronic address: hcui@swu.edu.cn.
Biochem Biophys Res Commun ; 523(3): 699-706, 2020 03 12.
Article em En | MEDLINE | ID: mdl-31948749
The WD repeat domain 5 (WDR5), also known as SWD3 and BIG-3, is often overexpressed in cancers, however its molecular function in cancer remains to be elucidated. In this study, we found that WDR5 promoted the proliferation and self-renewal of glioblastoma and neuroblastoma cells. The data from databases and Western blot assay showed that CARM1 is a downstream gene of WDR5-Myc axis. In addition, we observed that WDR5 promoted the binding of Myc to CARM1 promoter by interacting with Myc and inducing histone 3 lysine 4 trimethylation (H3K4me3). Dual luciferase reporter system indicated that Myc binds to the upstream region (-520 to -515) before transcription start site (TSS) of CARM1 promoter. These findings suggest a novel regulatory model for the proliferation and tumorigenesis of glioblastoma and neuroblastoma by WDR5-Myc axis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Proteínas Proto-Oncogênicas c-myc / Glioblastoma / Peptídeos e Proteínas de Sinalização Intracelular / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Proteínas Proto-Oncogênicas c-myc / Glioblastoma / Peptídeos e Proteínas de Sinalização Intracelular / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos