The Antimicrobial Activity of Mononuclear Ruthenium(II) Complexes Containing the dppz Ligand.
Chempluschem
; 83(7): 643-650, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-31950622
ABSTRACT
The cis-α isomer of [Ru(bb7 )(dppz)]2+ (dppz=dipyrido[3,2-a2',3'-c]phenazine; bb7 =bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-alkane) has been synthesised. The minimum inhibitory concentrations and the minimum bactericidal concentrations of [Ru(bb7 )(dppz)]2+ and its parent complex [Ru(phen)2 (dppz)]2+ (phen=1,10-phenanthroline) were determined against a range of bacteria. The results showed that both ruthenium complexes exhibited good activity against Gram-positive bacteria, but [Ru(bb7 )(dppz)]2+ showed at least eightfold better activity against the Gram-negative bacteria than [Ru(phen)2 (dppz)]2+ . Luminescence assays demonstrated that [Ru(bb7 )(dppz)]2+ accumulated in a Gram-negative bacterium to the same degree as in a Gram-positive species, and assays with liposomes showed that [Ru(bb7 )(dppz)]2+ interacted more strongly with membranes than the parent [Ru(phen)2 (dppz)]2+ complex. The DNA binding affinity for [Ru(bb7 )(dppz)]2+ was determined to be 6.7 × 106 m-1 . Although more toxic to eukaryotic cells than [Ru(phen)2 (dppz)]2+ , [Ru(bb7 )(dppz)]2+ exhibited greater activity against bacteria than eukaryotic cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chempluschem
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália