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Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.
Kawakubo, Mitsuhiro; Tanaka, Miyako; Ochi, Kozue; Watanabe, Akiko; Saka-Tanaka, Marie; Kanamori, Yohei; Yoshioka, Naoki; Yamashita, Satoko; Goto, Moritaka; Itoh, Michiko; Shirakawa, Ibuki; Kanai, Sayaka; Suzuki, Hiromi; Sawada, Makoto; Ito, Ayaka; Ishigami, Masatoshi; Fujishiro, Mitsuhiro; Arima, Hiroshi; Ogawa, Yoshihiro; Suganami, Takayoshi.
Afiliação
  • Kawakubo M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Tanaka M; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ochi K; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan. tanaka@riem.nagoya-u.ac.jp.
  • Watanabe A; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan. tanaka@riem.nagoya-u.ac.jp.
  • Saka-Tanaka M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Kanamori Y; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Yoshioka N; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Yamashita S; Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Goto M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Itoh M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Shirakawa I; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kanai S; Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya, Japan.
  • Suzuki H; Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya, Japan.
  • Sawada M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Ito A; Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ishigami M; Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan.
  • Fujishiro M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Arima H; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ogawa Y; Department of Brain Function, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
  • Suganami T; Department of Molecular Pharmacokinetics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sci Rep ; 10(1): 983, 2020 01 22.
Article em En | MEDLINE | ID: mdl-31969650
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Carcinoma Hepatocelular / Substâncias Protetoras / Inibidores da Dipeptidil Peptidase IV / Hepatopatia Gordurosa não Alcoólica / Cirrose Hepática / Neoplasias Hepáticas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Carcinoma Hepatocelular / Substâncias Protetoras / Inibidores da Dipeptidil Peptidase IV / Hepatopatia Gordurosa não Alcoólica / Cirrose Hepática / Neoplasias Hepáticas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido