SYNPLA, a method to identify synapses displaying plasticity after learning.
Proc Natl Acad Sci U S A
; 117(6): 3214-3219, 2020 02 11.
Article
em En
| MEDLINE
| ID: mdl-31974314
ABSTRACT
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Mapeamento de Interação de Proteínas
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Ensaios de Triagem em Larga Escala
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Aprendizagem
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2020
Tipo de documento:
Article