Sepsis induced cognitive impairments by disrupting hippocampal parvalbumin interneuron-mediated inhibitory network via a D4-receptor mechanism.

Ji, Muhuo; Li, Shuming; Zhang, Ling; Gao, Yuzhu; Zeng, Qiuting; Mao, Minjie; Yang, Jianjun

Ji, Muhuo; Li, Shuming; Zhang, Ling; Gao, Yuzhu; Zeng, Qiuting; Mao, Minjie; Yang, Jianjun.

Afiliação

Ji M; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Nanjing, China.
Li S; Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Zhang L; Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Gao Y; Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Zeng Q; Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Mao M; Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Yang J; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Nanjing, China.

Aging (Albany NY) ; 12(3): 2471-2484, 2020 02 04.

Article em En | MEDLINE | ID: mdl-32019903

Assuntos

Disfunção Cognitiva/metabolismo; Hipocampo/metabolismo; Interneurônios/metabolismo; Receptores de Dopamina D4/metabolismo; Sepse/complicações; Animais; Disfunção Cognitiva/etiologia; Ritmo Gama/fisiologia; Masculino; Parvalbuminas/metabolismo; Ratos; Ratos Sprague-Dawley; Sepse/metabolismo

Palavras-chave

D4 receptor; cognitive impairment; parvalbumin; sepsis; Î³ oscillation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Receptores de Dopamina D4 / Disfunção Cognitiva / Hipocampo / Interneurônios Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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