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Impact of obstructive sleep apnea on silent cerebral small vessel disease: a systematic review and meta-analysis.
Chokesuwattanaskul, Anthipa; Lertjitbanjong, Ploypin; Thongprayoon, Charat; Bathini, Tarun; Sharma, Konika; Mao, Michael A; Cheungpasitporn, Wisit; Chokesuwattanaskul, Ronpichai.
Afiliação
  • Chokesuwattanaskul A; Division of Neurology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. Electronic address: anthipa_pim@yahoo.com.
  • Lertjitbanjong P; Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
  • Thongprayoon C; Department of Internal Medicine Mayo Clinic, Rochester, MN, USA.
  • Bathini T; Department of Internal Medicine, University of Arizona, Tucson, AZ, USA.
  • Sharma K; Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
  • Mao MA; Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.
  • Cheungpasitporn W; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  • Chokesuwattanaskul R; King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Sleep Med ; 68: 80-88, 2020 04.
Article em En | MEDLINE | ID: mdl-32028230
BACKGROUND: Cerebral small vessel disease (CSVD) is a well-known cause of vascular dementia, a leading medical morbidity in the aging population. Obstructive sleep apnea (OSA) has been validated as a cardiovascular risk factor. However, the relationship between these two clinical syndromes is not well established. We aimed to assess the association between OSA and CSVD. METHODS: Databases were searched from inception through May 2019. Studies that reported incidence or odd ratios of CSVD in patients with OSA were included. Effect estimates from the individual studies were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: A total of 14 observational studies comprising of 4335 patients were included into the analysis. Compared to patients without OSA, patients with OSA were significantly associated with CSVD magnetic resonance imaging (MRI) findings of white matter hyperintensity (WMH) and asymptomatic lacunar infarction (ALI) with a pooled OR of 2.31 (95% confidence interval [CI], 1.46-3.66, I2 = 79%) and 1.78 (95% CI, 1.06-3.01, I2 = 41%), respectively. However, there was no significant association between OSA and findings of cerebral microbleeds (CMBs), with a pooled odds ratio (OR) of 2.15 (95% CI, 0.64-7.29, I2 = 55%). CONCLUSIONS: Our study demonstrated the association between OSA and CSVD MRI findings of white matter hyperintensity (WMH) and asymptomatic lacunar infarction (ALI) when compared to patients without OSA. The absence of an association of CMBs findings with OSA could be due either by a lower sensitivity of neuroimaging techniques utilized to detect CMBs or a potentially different pathogenesis of CMBs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apneia Obstrutiva do Sono / Doenças de Pequenos Vasos Cerebrais / Acidente Vascular Cerebral Lacunar Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Sleep Med Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apneia Obstrutiva do Sono / Doenças de Pequenos Vasos Cerebrais / Acidente Vascular Cerebral Lacunar Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Sleep Med Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda