Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells.

Liang, Chen; Feng, Zhiyuan; Manthari, Ram Kumar; Wang, Chong; Han, Yongli; Fu, Weixiang; Wang, Jundong; Zhang, Jianhai

Liang, Chen; Feng, Zhiyuan; Manthari, Ram Kumar; Wang, Chong; Han, Yongli; Fu, Weixiang; Wang, Jundong; Zhang, Jianhai.

Afiliação

Liang C; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Feng Z; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Manthari RK; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Wang C; Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, People's Republic of China.
Han Y; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Fu W; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Wang J; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China.
Zhang J; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, People's Republic of China. Electronic address: jianhaiz@163.com.

J Hazard Mater ; 391: 122227, 2020 06 05.

Article em En | MEDLINE | ID: mdl-32044640

Assuntos

Arsênio/toxicidade; Autofagia/efeitos dos fármacos; Animais; Proteína Beclina-1/genética; Proteína Beclina-1/metabolismo; Linhagem Celular Tumoral; Classe III de Fosfatidilinositol 3-Quinases/genética; Camundongos; Fosfatidilinositol 3-Quinases; RNA Interferente Pequeno/genética; Transdução de Sinais/efeitos dos fármacos; Sirolimo/farmacologia; Serina-Treonina Quinases TOR/antagonistas & inibidores; Serina-Treonina Quinases TOR/genética

Palavras-chave

Arsenic; Autophagy; Beclin1-Vps34/PI3K complex; MTOR pathway; Male reproductive toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Autofagia Limite: Animals Idioma: En Revista: J Hazard Mater Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

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