Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing.

Sharma, Swati; Kulkarni, Chirag; Kulkarni, Manish M; Ali, Rafat; Porwal, Konica; Chattopadhyay, Naibedya; Tewari, Deepshikha; Verma, Sandeep

Sharma, Swati; Kulkarni, Chirag; Kulkarni, Manish M; Ali, Rafat; Porwal, Konica; Chattopadhyay, Naibedya; Tewari, Deepshikha; Verma, Sandeep.

Afiliação

Sharma S; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. sverma@iitk.ac.in.
Kulkarni C; Endocrinology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Kulkarni MM; Centre for Nanoscience, Indian Institute of Technology Kanpur, Kanpur 208016, India. dtewari@iitk.ac.in.
Ali R; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. sverma@iitk.ac.in.
Porwal K; Endocrinology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Chattopadhyay N; Endocrinology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Tewari D; Centre for Nanoscience, Indian Institute of Technology Kanpur, Kanpur 208016, India. dtewari@iitk.ac.in.
Verma S; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India. sverma@iitk.ac.in.

Chem Commun (Camb) ; 56(20): 3043-3046, 2020 Mar 10.

Article em En | MEDLINE | ID: mdl-32048649

RESUMO

We demonstrate the ability of two tripeptides to promote proliferation and modulate the mechanical properties of human mesenchymal stem cells (hMSCs). Notably, Young's modulus of peptide-treated hMSCs was found to be â¼2 fold higher compared to the control group. These peptides promoted wound healing in hMSCs, without stimulating osteogenic and adipogenic differentiation, thus showing high potential in vascular tissue engineering applications.

Assuntos

Células-Tronco Mesenquimais/efeitos dos fármacos; Oligopeptídeos/farmacologia; Cicatrização/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Humanos; Conformação Molecular; Oligopeptídeos/química; Engenharia Tecidual

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Cicatrização / Células-Tronco Mesenquimais Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido

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