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A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation.
Charmetant, Xavier; Teuma, Cécile; Lake, Jennifer; Dijoud, Frédérique; Frochot, Vincent; Deeb, Abbas.
Afiliação
  • Charmetant X; Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
  • Teuma C; Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
  • Lake J; Immunology Cancer Research (ImmuCare), Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France.
  • Dijoud F; Institute of Physiology, University of Zurich, Zürich, Switzerland.
  • Frochot V; Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.
  • Deeb A; Department of Physiology, Hôpital Tenon, APHP, Paris Cedex 20, France.
Clin Kidney J ; 13(1): 42-45, 2020 Feb.
Article em En | MEDLINE | ID: mdl-32082551
ABSTRACT
The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Kidney J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Kidney J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França