Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer.

Kim, Kyungsoo; Park, Seyeon; Park, Seong Yong; Kim, Gamin; Park, Su Myeong; Cho, Jae-Won; Kim, Da Hee; Park, Young Min; Koh, Yoon Woo; Kim, Hye Ryun; Ha, Sang-Jun; Lee, Insuk

Kim, Kyungsoo; Park, Seyeon; Park, Seong Yong; Kim, Gamin; Park, Su Myeong; Cho, Jae-Won; Kim, Da Hee; Park, Young Min; Koh, Yoon Woo; Kim, Hye Ryun; Ha, Sang-Jun; Lee, Insuk.

Afiliação

Kim K; Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, Korea.
Park S; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, Korea.
Park SY; Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Kim G; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Park SM; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Cho JW; Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, Korea.
Kim DH; Department of Otorhinolaryngology, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Park YM; Department of Otorhinolaryngology, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Koh YW; Department of Otorhinolaryngology, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Kim HR; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, College of Medicine, Yonsei University, Seoul, 03722, Korea.
Ha SJ; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, Korea. sjha@yonsei.ac.kr.
Lee I; Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, Korea. insuklee@yonsei.ac.kr.

Genome Med ; 12(1): 22, 2020 02 28.

Article em En | MEDLINE | ID: mdl-32111241

Assuntos

Carcinoma Pulmonar de Células não Pequenas/genética; Proteínas de Grupo de Alta Mobilidade/genética; Neoplasias Pulmonares/genética; Linfócitos do Interstício Tumoral/imunologia; Melanoma/genética; Transcriptoma; Animais; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Feminino; Proteínas de Grupo de Alta Mobilidade/metabolismo; Humanos; Inibidores de Checkpoint Imunológico/uso terapêutico; Neoplasias Pulmonares/tratamento farmacológico; Melanoma/tratamento farmacológico; Camundongos; Camundongos Endogâmicos C57BL; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Receptor de Morte Celular Programada 1/genética; Receptor de Morte Celular Programada 1/metabolismo; RNA-Seq; Análise de Célula Única; Células Tumorais Cultivadas

Palavras-chave

Anti-PD-1 immunotherapy; Immune checkpoint; Intra-tumoral T cell exhaustion; Single-cell RNA sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Grupo de Alta Mobilidade / Linfócitos do Interstício Tumoral / Carcinoma Pulmonar de Células não Pequenas / Transcriptoma / Neoplasias Pulmonares / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: Genome Med Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido

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