Chitosan-based electrospun membranes: Effects of solution viscosity, coagulant and crosslinker.
Carbohydr Polym
; 235: 115976, 2020 May 01.
Article
em En
| MEDLINE
| ID: mdl-32122507
ABSTRACT
Chitosan-based membranes were prepared via electrospinning technique using a low concentrated acetic acid solution as solvent and poly(ethylene oxide) as co-spinning agent. Different solutions were rheologically characterized and increasing the solution viscosity was found to correspond to a better-defined morphology. The membranes were first subjected to a coagulation process with different baths in order to stabilize chitosan and the mats were found not able to withstand a strongly basic environment. Subsequently, a physical and a chemical crosslinking approach were separately optimized to obtain stable mats whose composition was assessed via thermogravimetric and spectroscopic techniques, proving in both cases the elimination of the co-spinning agent. Above all, the ionically crosslinked mats represent a class of extremely promising biomedical products being probably highly biocompatible and characterized by thin and homogenous nanofibers with a diameter of 200â¯nm, thus showing the ideal structure to foster cell viability.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Reagentes de Ligações Cruzadas
/
Quitosana
/
Membranas Artificiais
/
Acetatos
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2020
Tipo de documento:
Article