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Advances in the Development of Therapeutics for Cytomegalovirus Infections.
Acosta, Edward; Bowlin, Terry; Brooks, Jennifer; Chiang, Lillian; Hussein, Islam; Kimberlin, David; Kauvar, Lawrence M; Leavitt, Randi; Prichard, Mark; Whitley, Richard.
Afiliação
  • Acosta E; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Bowlin T; Microbiotix, Inc, Worcester, Massachusetts, USA.
  • Brooks J; Microbiotix, Inc, Worcester, Massachusetts, USA.
  • Chiang L; Evrys Bio, LLC, Doylestown, Pennsylvania, USA.
  • Hussein I; Microbiotix, Inc, Worcester, Massachusetts, USA.
  • Kimberlin D; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Kauvar LM; Trellis Bioscience, LLC, Redwood City, California, USA.
  • Leavitt R; Merck, West Point, Pennsylvania, USA.
  • Prichard M; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Whitley R; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Infect Dis ; 221(Suppl 1): S32-S44, 2020 03 05.
Article em En | MEDLINE | ID: mdl-32134483
ABSTRACT
The development of therapeutics for cytomegalovirus (CMV) infections, while progressing, has not matched the pace of new treatments of human immunodeficiency virus (HIV) infections; nevertheless, recent developments in the treatment of CMV infections have resulted in improved human health and perhaps will encourage the development of new therapeutic approaches. First, the deployment of ganciclovir and valganciclovir for both the prevention and treatment of CMV infections and disease in transplant recipients has been further improved with the licensure of the efficacious and less toxic letermovir. Regardless, late-onset CMV disease, specifically pneumonia, remains problematic. Second, the treatment of congenital CMV infections with valganciclovir has beneficially improved both hearing and neurologic outcomes, both fundamental advances for these children. In these pediatric studies, viral load was decreased but not eliminated. Thus, an important lesson learned from studies in both populations is the need for new antiviral agents and the necessity for combination therapies as has been shown to be beneficial in the treatment of HIV infections, among others. The development of monoclonal antibodies, sirtuins, and cyclopropovir may provide new treatment options.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por Citomegalovirus / Citomegalovirus / Desenvolvimento de Medicamentos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por Citomegalovirus / Citomegalovirus / Desenvolvimento de Medicamentos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos