Your browser doesn't support javascript.
loading
Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.
Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J.
Afiliação
  • Butts B; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Ahmed MI; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Bajaj NS; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Cox Powell P; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Pat B; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Litovsky S; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Gupta H; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Lloyd SG; Department of Veterans Affairs Medical Center, Birmingham, Alabama.
  • Denney TS; Department of Cardiology, Valley Health System, Paramus, New Jersey.
  • Zhang X; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
  • Aban I; Department of Veterans Affairs Medical Center, Birmingham, Alabama.
  • Sadayappan S; Department of Electrical and Computer Engineering, Auburn University School of Engineering, Auburn, Alabama.
  • McNamara JW; Department of Electrical and Computer Engineering, Auburn University School of Engineering, Auburn, Alabama.
  • Watson MJ; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama.
  • Ferrario CM; Division of Cardiovascular Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Collawn JF; Division of Cardiovascular Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Lewis C; Division of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, North Carolina.
  • Davies JE; Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, North Carolina.
  • Dell'Italia LJ; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.
JACC Basic Transl Sci ; 5(2): 109-122, 2020 Feb.
Article em En | MEDLINE | ID: mdl-32140620
ABSTRACT
Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2020 Tipo de documento: Article