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Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh.
Williams, Frank B; Kader, Abdul; Colgate, E Ross; Dickson, Dorothy M; Carmolli, Marya; Uddin, Muhammad Ikhtear; Sharmin, Salma; Islam, Shahidul; Bhuiyan, Taufiqur Rahman; Alam, Masud; Nayak, Uma; Mychaleckyj, Josyf C; Petri, William A; Haque, Rashidul; Qadri, Firdausi; Kirkpatrick, Beth D; Lee, Benjamin.
Afiliação
  • Williams FB; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Kader A; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Colgate ER; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Dickson DM; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Carmolli M; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Uddin MI; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Sharmin S; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Islam S; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Bhuiyan TR; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Alam M; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Nayak U; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
  • Mychaleckyj JC; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
  • Petri WA; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
  • Haque R; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Qadri F; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Kirkpatrick BD; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
  • Lee B; The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
J Infect Dis ; 224(7): 1147-1151, 2021 10 13.
Article em En | MEDLINE | ID: mdl-32157282
ABSTRACT
Secretor status controls mucosal histo-blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Aleitamento Materno / Rotavirus / Vacinas contra Rotavirus Limite: Adult / Female / Humans / Infant / Male / Newborn País/Região como assunto: Asia Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Aleitamento Materno / Rotavirus / Vacinas contra Rotavirus Limite: Adult / Female / Humans / Infant / Male / Newborn País/Região como assunto: Asia Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos