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The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata.
Meah, Nekma; Wall, Dmitri; York, Katherine; Bhoyrul, Bevin; Bokhari, Laita; Sigall, Daniel Asz; Bergfeld, Wilma F; Betz, Regina C; Blume-Peytavi, Ulrike; Callender, Valerie; Chitreddy, Vijaya; Combalia, Andrea; Cotsarelis, George; Craiglow, Brittany; Donovan, Jeff; Eisman, Samantha; Farrant, Paul; Green, Jack; Grimalt, Ramon; Harries, Matthew; Hordinsky, Maria; Irvine, Alan D; Itami, Satoshi; Jolliffe, Victoria; King, Brett; Lee, Won-Soo; McMichael, Amy; Messenger, Andrew; Mirmirani, Paradi; Olsen, Elise; Orlow, Seth J; Piraccini, Bianca Maria; Rakowska, Adriana; Reygagne, Pascal; Roberts, Janet L; Rudnicka, Lidia; Shapiro, Jerry; Sharma, Pooja; Tosti, Antonella; Vogt, Annika; Wade, Martin; Yip, Leona; Zlotogorski, Abraham; Sinclair, Rodney.
Afiliação
  • Meah N; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Wall D; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • York K; Netcare Greenacres Hospital, Port Elizabeth, South Africa.
  • Bhoyrul B; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Bokhari L; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Sigall DA; Dermalomas Clinic, Mexico City, Mexico.
  • Bergfeld WF; Departments of Dermatology and Pathology, Cleveland Clinic, Cleveland, Ohio.
  • Betz RC; Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Blume-Peytavi U; Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Callender V; Howard University College of Medicine, Washington, DC.
  • Chitreddy V; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Combalia A; Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain.
  • Cotsarelis G; Department of Dermatology University of Pennsylvania School of Medicine Philadelphia, Philadelphia, Pennsylvania.
  • Craiglow B; Dermatology Physicians of Connecticut, Fairfield, Connecticut.
  • Donovan J; Donovan Hair Clinic, Whistler, Canada.
  • Eisman S; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Farrant P; Brighton and Sussex University Hospitals Trust, Brighton, United Kingdom.
  • Green J; St. Vincent's Hospital, Melbourne, Australia.
  • Grimalt R; Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain.
  • Harries M; Department of Dermatology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
  • Hordinsky M; Dermatology, M Health Fairview Discovery Pediatric Specialty Clinic, Minneapolis, Minnesota.
  • Irvine AD; St. James's Hospital and National and International Sin Registry (NISR) Solutions, Dublin, Ireland.
  • Itami S; Department of Dermatology, Oita University, Yufu City, Japan.
  • Jolliffe V; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • King B; Yale School of Medicine, Yale Dermatology, Middlebury, Connecticut.
  • Lee WS; Department of Dermatology Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • McMichael A; Department of Dermatology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
  • Messenger A; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
  • Mirmirani P; The Permanente Medical Group, Vallejo, California.
  • Olsen E; Duke Dermatology Clinic, Durham, North Carolina.
  • Orlow SJ; Director of Pediatric Dermatology, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York; Department of Pediatrics, New York University Medical Center, New York, New York.
  • Piraccini BM; Deputy for International Relations, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Rakowska A; Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
  • Reygagne P; Cabinet Pascal Reygagne (Lecourbe), Paris, France.
  • Roberts JL; Northwest Dermatology Institute, Portland, Oregon.
  • Rudnicka L; Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
  • Shapiro J; Director of Pediatric Dermatology, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
  • Sharma P; Sinclair Dermatology, East Melbourne, Melbourne, Australia.
  • Tosti A; Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Vogt A; Department of Dermatology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Wade M; The London Skin and Hair Clinic, London, United Kingdom.
  • Yip L; Gabba Dermatology, Brisbane, Australia.
  • Zlotogorski A; Faculty of Medicine, Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Sinclair R; Sinclair Dermatology, East Melbourne, Melbourne, Australia. Electronic address: rodneyds@unimelb.edu.au.
J Am Acad Dermatol ; 83(1): 123-130, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32165196
ABSTRACT

BACKGROUND:

A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials.

OBJECTIVE:

To produce an international consensus statement on the use and utility of various treatments for AA.

METHODS:

Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus.

RESULTS:

In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies.

LIMITATIONS:

The study included a comprehensive list of systemic treatments for AA but not all treatments used.

CONCLUSION:

Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alopecia em Áreas Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Am Acad Dermatol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alopecia em Áreas Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Am Acad Dermatol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália