Leishmanicidal phenolic compounds derived from Dalbergia cultrata.
Nat Prod Res
; 35(23): 4907-4915, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-32208778
ABSTRACT
Leishmaniasis is a protozoan tropical infection that is estimated to be more than 0.3 million new cases occur annually worldwide. A novel phenolic compound, cultratin A (1), was isolated as a leishmanicidal constituent from the timber of Dalbergia cultrata, along with three known neoflavanoids (2, 3, 4), two benzofurans (5, 6), and two phenolic compounds (7, 8). Their structures were determined using spectral methods. Among them, a new compound (1) and 4-(S)-methoxydalbergione (2) showed effective leishmanicidal activities (IC50 2.0 and 2.6 µM, respectively), while compound 8 showed moderate activity (IC50 11 µM). The cytotoxicity of compounds 1 and 2 was also weaker than that of the other compounds.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Leishmaniose
/
Dalbergia
/
Antiprotozoários
Limite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão