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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Schauer, Nathan J; Liu, Xiaoxi; Magin, Robert S; Doherty, Laura M; Chan, Wai Cheung; Ficarro, Scott B; Hu, Wanyi; Roberts, Rebekka M; Iacob, Roxana E; Stolte, Björn; Giacomelli, Andrew O; Perera, Sumner; McKay, Kyle; Boswell, Sarah A; Weisberg, Ellen L; Ray, Arghya; Chauhan, Dharminder; Dhe-Paganon, Sirano; Anderson, Ken C; Griffin, James D; Li, Jianing; Hahn, William C; Sorger, Peter K; Engen, John R; Stegmaier, Kimberly; Marto, Jarrod A; Buhrlage, Sara J.
Afiliação
  • Schauer NJ; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Liu X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Magin RS; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Doherty LM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Chan WC; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ficarro SB; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Hu W; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Roberts RM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Iacob RE; Department of Systems Biology and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Stolte B; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Giacomelli AO; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Perera S; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • McKay K; Department of Oncologic Pathology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Boswell SA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Weisberg EL; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ray A; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Chauhan D; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Dhe-Paganon S; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.
  • Anderson KC; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, LMU Munich, Munich, Germany.
  • Griffin JD; The Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Li J; The Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Sorger PK; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Engen JR; Harvard College, Cambridge, MA, USA.
  • Stegmaier K; Department of Chemistry, University of Vermont, Burlington, VT, USA.
  • Marto JA; Department of Systems Biology and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Buhrlage SJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sci Rep ; 10(1): 5324, 2020 03 24.
Article em En | MEDLINE | ID: mdl-32210275
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Proteína Supressora de Tumor p53 / Peptidase 7 Específica de Ubiquitina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Proteína Supressora de Tumor p53 / Peptidase 7 Específica de Ubiquitina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido