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ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
Gou, Wenfeng; Li, Zengqiang; Xu, Xiaobo; Shen, Jiwei; Guo, Ming; Zhou, Xuejiao; Zhang, Xiaoning; Wu, Yingliang; Zhai, Xin; Zuo, Daiying.
Afiliação
  • Gou W; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Scienc
  • Li Z; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Xu X; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Shen J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Guo M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Zhou X; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Zhang X; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Wu Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Zhai X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zhaixin_syphu@126.com.
  • Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zuodaiying@163.com.
Biochim Biophys Acta Mol Cell Res ; 1867(7): 118712, 2020 07.
Article em En | MEDLINE | ID: mdl-32224191
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Inibidores de Proteínas Quinases / Quinase do Linfoma Anaplásico / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Inibidores de Proteínas Quinases / Quinase do Linfoma Anaplásico / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda