Highly Regio- and Stereoselective Ni-Catalyzed Hydrocyanation of 1,3-Enynes.

Sun, Feilong; Ni, Jie; Cheng, Gui-Juan; Fang, Xianjie

Sun, Feilong; Ni, Jie; Cheng, Gui-Juan; Fang, Xianjie.

Afiliação

Sun F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
Ni J; Warshel Institute for Computational Biology, School of, Life and Health Sciences, The Chinese University of, Hong Kong (Shenzhen), Shenzhen, 518172, P. R. China.
Cheng GJ; Warshel Institute for Computational Biology, School of, Life and Health Sciences, The Chinese University of, Hong Kong (Shenzhen), Shenzhen, 518172, P. R. China.
Fang X; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.

Chemistry ; 26(27): 5956-5960, 2020 May 12.

Article em En | MEDLINE | ID: mdl-32237171

ABSTRACT

ABSTRACT

A highly regio- and stereoselective hydrocyanation of 1,3-enynes was implemented by nickel/diphosphine catalysts. A wide range of highly regio- and stereoselective alkenyl nitriles were efficiently prepared. In this transformation, both the tethered alkene and the ligand play key roles in the reactivity and selectivity. The origin of regioselectivity was understood preliminarily by DFT studies.

Palavras-chave

1,3-enynes; alkene effect; alkenyl nitriles; hydrocyanation; nickel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article

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