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Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption.
Person, Jon M; Welch, Bradley A; Spann, Redin A; Harris, Kwamie K; Pride, Yilianys; Tucci, Michelle A; Taylor, Erin B; Grayson, Bernadette E.
Afiliação
  • Person JM; Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Welch BA; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Spann RA; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Harris KK; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Pride Y; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Tucci MA; Department of Anesthesiology, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Taylor EB; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
  • Grayson BE; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America; Department of Anesthesiology, University of Mississippi Medical Center, Jackson, MS 39216, United States of America. Electronic address: bgrayson@umc.edu.
J Neuroimmunol ; 343: 577226, 2020 06 15.
Article em En | MEDLINE | ID: mdl-32247229
ABSTRACT
Spinal cord injury (SCI) results in perturbations to the immune system leading to increased infection susceptibility. In parallel, the consumption of high-fat diets (HFD) leads to a chronic inflammation in circulation and body tissues. We investigated the impact of 16 weeks of HFD on chronically-injured rats. SCI rats under both chow and HFD showed peripheral leukocyte changes that include reduced percentages of total, helper and cytotoxic T, and natural killer cells. Expression of immune-related genes in the spleen and thymus reflected the impact of both chronic injury and diet. Changes to the immune system following SCI are adversely impacted by HFD consumption.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Baço / Timo / Linfócitos T / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: J Neuroimmunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Baço / Timo / Linfócitos T / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: J Neuroimmunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos