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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
Fell, Jay B; Fischer, John P; Baer, Brian R; Blake, James F; Bouhana, Karyn; Briere, David M; Brown, Karin D; Burgess, Laurence E; Burns, Aaron C; Burkard, Michael R; Chiang, Harrah; Chicarelli, Mark J; Cook, Adam W; Gaudino, John J; Hallin, Jill; Hanson, Lauren; Hartley, Dylan P; Hicken, Erik J; Hingorani, Gary P; Hinklin, Ronald J; Mejia, Macedonio J; Olson, Peter; Otten, Jennifer N; Rhodes, Susan P; Rodriguez, Martha E; Savechenkov, Pavel; Smith, Darin J; Sudhakar, Niranjan; Sullivan, Francis X; Tang, Tony P; Vigers, Guy P; Wollenberg, Lance; Christensen, James G; Marx, Matthew A.
Afiliação
  • Fell JB; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Fischer JP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Baer BR; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Blake JF; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Bouhana K; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Briere DM; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Brown KD; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Burgess LE; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Burns AC; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Burkard MR; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Chiang H; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Chicarelli MJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Cook AW; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Gaudino JJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hallin J; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Hanson L; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hartley DP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hicken EJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hingorani GP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hinklin RJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Mejia MJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Olson P; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Otten JN; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Rhodes SP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Rodriguez ME; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Savechenkov P; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Smith DJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Sudhakar N; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Sullivan FX; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Tang TP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Vigers GP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Wollenberg L; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Christensen JG; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Marx MA; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
J Med Chem ; 63(13): 6679-6693, 2020 07 09.
Article em En | MEDLINE | ID: mdl-32250617
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos