Modulation of endoplasmic reticulum stress response in gut-origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation.

Zaky, Doaa A; Wadie, Walaa; Eldehna, Wagdy M; El Kerdawy, Ahmed M; Abdallah, Dalaal M; El Abhar, Hanan S

Zaky, Doaa A; Wadie, Walaa; Eldehna, Wagdy M; El Kerdawy, Ahmed M; Abdallah, Dalaal M; El Abhar, Hanan S.

Afiliação

Zaky DA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box 11562, Egypt. Electronic address: doaa.zaky@pharma.cu.edu.eg.
Wadie W; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box 11562, Egypt.
Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Egypt.
El Kerdawy AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box 11562, Egypt.
Abdallah DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box 11562, Egypt.
El Abhar HS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box 11562, Egypt; Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, P.O. Box 11835, Egypt

Life Sci ; 252: 117654, 2020 Jul 01.

Article em En | MEDLINE | ID: mdl-32277979

Assuntos

Encefalopatias/fisiopatologia; Estresse do Retículo Endoplasmático/fisiologia; Sepse/complicações; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores; Fator 4 Ativador da Transcrição/genética; Animais; Encefalopatias/etiologia; Encefalopatias/prevenção & controle; Modelos Animais de Doenças; Masculino; RNA Mensageiro/metabolismo; Ratos; Ratos Sprague-Dawley; Sepse/tratamento farmacológico; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; eIF-2 Quinase/metabolismo

Palavras-chave

Cecal ligation and perforation; Endoplasmic reticulum stress; Gut-brain axis; Sepsis-associated encephalopathy; Unfolded protein response; VEGFR2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatias / Sepse / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Estresse do Retículo Endoplasmático Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

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