Assessment of <i>in vitro</i> inhibitory effects of novel anti MRSA benzoquinolizine fluoroquinolone WCK 771 (levonadifloxacin) and its metabolite on human liver cytochrome P450 enzymes.

Chavan, Rajesh; Zope, Vineet; Chavan, Nilesh; Shaikh, Javeed; Patil, Kiran; Yeole, Ravindra; Bhagwat, Sachin; Patel, Mahesh

Assessment of in vitro inhibitory effects of novel anti MRSA benzoquinolizine fluoroquinolone WCK 771 (levonadifloxacin) and its metabolite on human liver cytochrome P450 enzymes.

Chavan, Rajesh; Zope, Vineet; Chavan, Nilesh; Shaikh, Javeed; Patil, Kiran; Yeole, Ravindra; Bhagwat, Sachin; Patel, Mahesh.

Afiliação

Chavan R; Wockhardt Research Centre, Aurangabad, India.
Zope V; Wockhardt Research Centre, Aurangabad, India.
Chavan N; Wockhardt Research Centre, Aurangabad, India.
Shaikh J; Wockhardt Research Centre, Aurangabad, India.
Patil K; Wockhardt Research Centre, Aurangabad, India.
Yeole R; Wockhardt Research Centre, Aurangabad, India.
Bhagwat S; Wockhardt Research Centre, Aurangabad, India.
Patel M; Wockhardt Research Centre, Aurangabad, India.

Xenobiotica ; 50(10): 1149-1157, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32283993

Assuntos

Antibacterianos/farmacologia; Fluoroquinolonas/farmacologia; Alanina; Antibacterianos/metabolismo; Inibidores das Enzimas do Citocromo P-450/farmacologia; Sistema Enzimático do Citocromo P-450/metabolismo; Fluoroquinolonas/metabolismo; Humanos; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Microssomos Hepáticos/metabolismo

Palavras-chave

CYP inhibition; Fluoroquinolone; HLM; levonadifloxacin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fluoroquinolonas / Antibacterianos Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido

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