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Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1.
Jupp, Bianca; Pitzoi, Silvia; Petretto, Enrico; Mar, Adam C; Oliver, Yolanda Pena; Jordan, Emily R; Taylor, Stephanie; Atanur, Santosh S; Srivastava, Prashant K; Saar, Kathrin; Hubner, Norbert; Sommer, Wolfgang H; Staehlin, Oliver; Spanagel, Rainer; Robinson, Emma S; Schumann, Gunter; Moreno, Margarita; Everitt, Barry J; Robbins, Trevor W; Aitman, Timothy J; Dalley, Jeffrey W.
Afiliação
  • Jupp B; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Pitzoi S; MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
  • Petretto E; MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
  • Mar AC; Duke-NUS Medical School, Singapore, Singapore.
  • Oliver YP; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Jordan ER; NYU School of Medicine, New York, USA.
  • Taylor S; School of Psychology, University of Sussex, Brighton, UK.
  • Atanur SS; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Srivastava PK; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Saar K; MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
  • Hubner N; MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK.
  • Sommer WH; Max Delbruck Centre for Molecular Medicine, Berlin, Germany.
  • Staehlin O; Max Delbruck Centre for Molecular Medicine, Berlin, Germany.
  • Spanagel R; Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
  • Robinson ES; Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
  • Schumann G; Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
  • Moreno M; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Everitt BJ; Centre for Population Neuroscience and Stratified Medicine, Institute of Psychiatry, Psychology and Neuroscience, King¹s College, London, UK.
  • Robbins TW; Department of Psychology & Health Research Centre (CEINSA), University of Almería, Almería, Spain.
  • Aitman TJ; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Dalley JW; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Sci Rep ; 10(1): 6684, 2020 04 21.
Article em En | MEDLINE | ID: mdl-32317713
ABSTRACT
Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unbiased, genome-wide approach to identify genetic markers associated with impulsivity in experimental animals. Herein we report a linkage study of a six-generational pedigree of adult rats phenotyped for one dimension of impulsivity, namely premature responding on the five-choice serial reaction time task, combined with genome wide sequencing and transcriptome analysis to identify candidate genes associated with the expression of the impulsivity trait. Premature responding was found to be heritable (h2 = 13-16%), with significant linkage (LOD 5.2) identified on chromosome 1. Fine mapping of this locus identified a number of polymorphic candidate genes, however only one, beta haemoglobin, was differentially expressed in both the founder strain and F6 generation. These findings provide novel insights into the genetic substrates and putative neurobiological mechanisms of impulsivity with broader translational relevance for impulsivity-related disorders in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Característica Quantitativa Herdável / Cromossomos de Mamíferos / Locos de Características Quantitativas / Comportamento Impulsivo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Característica Quantitativa Herdável / Cromossomos de Mamíferos / Locos de Características Quantitativas / Comportamento Impulsivo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido