Maternal host responses to poly(I:C) during pregnancy leads to both dysfunctional immune profiles and altered behaviour in the offspring.
Am J Reprod Immunol
; 84(2): e13260, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32365239
ABSTRACT
PROBLEM:
Autism spectrum disorder (ASD)-like phenotypes in murine models are linked to elevated pro-inflammatory cytokine profiles caused by maternal immune activation (MIA), but whether MIA alters the immune response in the offspring remains unclear. METHOD OF STUDY Polyinosinicpolycytidylic acid (poly[IC]) was used to induce MIA in immunocompetent and control TLR3-deficient pregnant mice, and cytokine levels were measured in maternal and foetal organs. Furthermore, cytokines and behaviour responses were tested after challenge with lipopolysaccharide in 7-day-old and adult mice.RESULTS:
MIA induced on E12 resulted in changes in the cytokine expression profile in maternal and foetal organs and correlated with TNFα and IL-18 dysregulation in immune organs and brains from neonatal mice born to MIA-induced dams. Such changes further correlated with altered behavioural responses in adulthood.CONCLUSION:
MIA induced by pathogens during pregnancy can interfere with the development of the foetal immune and nervous systems leading to dysfunctional immune responses and behaviour in offspring.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Viroses
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Gravidez
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Poli I-C
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Transtorno do Espectro Autista
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Doenças do Sistema Imunitário
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Austrália