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Does Smoking Cessation at Primary Diagnosis Reduce the Recurrence Risk of Nonmuscle-Invasive Bladder Cancer? Results of a Prospective Study.
Serretta, Vincenzo; Di Maida, Fabrizio; Baiamonte, Davide; Vella, Marco; Pavone, Carlo; Cacciatore, Loris; Valerio, Maria Rosaria; Scalici Gesolfo, Cristina; Sanfilippo, Chiara.
Afiliação
  • Serretta V; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy, vserretta@libero.it.
  • Di Maida F; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Baiamonte D; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Vella M; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Pavone C; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Cacciatore L; Division of Urology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Valerio MR; Division of Medical Oncology, Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy.
  • Scalici Gesolfo C; Division of Urology, Paolo Borsellino Hospital, Marsala, Italy.
  • Sanfilippo C; Statistics, GSTU Foundation, Palermo, Italy.
Urol Int ; 104(5-6): 396-401, 2020.
Article em En | MEDLINE | ID: mdl-32369816
ABSTRACT

INTRODUCTION:

Evidence that smoking cessation at first diagnosis of nonmuscle-invasive bladder cancer (NMIBC) reduces the risk of recurrence is lacking. The aim of our prospective study was to analyze the association between patients' changes in smoking habits after diagnosis and recurrence-free survival (RFS). PATIENTS After transurethral resection of primary NMIBC, patients were classified as "ex-smokers," i.e., those definitively stopping, and as "active smokers," i.e., those continuing or restarting to smoke. Smoking status was reassessed every 3 months during the first year and every 6 months thereafter. Data on patients' demographics, smoking status, tumor characteristics, treatments, and follow-up were collected. Statistical analysis was performed adopting SPSS 15.0.1 and R3.4.2 software.

RESULTS:

Out of 194 patients, 67 (34.5%) quit smoking after the diagnosis, while 127 (65.5%) did not. The clinical and pathological characteristics were homogeneously distributed. At a median follow-up of 38 months, 106 patients (54.6%) recurred, 33 (49.2%) ex- and 73 (60.3%) active smokers with a 3-year RFS of 42.3 and 50.7%, respectively (p = 0.55). No statistically significant association between recurrence, pathological features of the primary tumor, and patient smoking habits after diagnosis was detected. Results were not statistically influenced by the intensity (cigarette/day) and duration (years) of smoking. In multivariate analysis, cigarette smoking cessation at diagnosis did not significantly reduce tumor recurrence.

CONCLUSION:

In our prospective study, more than half of our patients recurred at 3 years. In multivariate analysis, smoking cessation did not significantly reduce tumor recurrence. However, the 8.4% reduction in favor of the ex-smokers suggests the need of larger studies with longer follow-ups. Surprisingly, only 35% of smokers definitively quit after diagnosis. The urologists should play a more active role to persuade the patients to stop smoking at first cancer diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Abandono do Hábito de Fumar / Recidiva Local de Neoplasia Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Urol Int Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Abandono do Hábito de Fumar / Recidiva Local de Neoplasia Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Urol Int Ano de publicação: 2020 Tipo de documento: Article
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