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Digital dermoscopic changes during follow-up of de-novo and nevus-associated melanoma: a cohort study.
Pampena, Riccardo; Manfreda, Valeria; Kyrgidis, Athanassios; Lai, Michela; Borsari, Stefania; Benati, Elisa; Lombardi, Mara; Bianchi, Luca; Zalaudek, Iris; Moscarella, Elvira; Lallas, Aimilios; Argenziano, Giuseppe; Pellacani, Giovanni; Longo, Caterina.
Afiliação
  • Pampena R; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Manfreda V; Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
  • Kyrgidis A; First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
  • Lai M; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Borsari S; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Benati E; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Lombardi M; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Bianchi L; Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.
  • Zalaudek I; Department of Dermatology and Venereology, University of Trieste, Trieste, Italy.
  • Moscarella E; Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Lallas A; First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
  • Argenziano G; Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Pellacani G; Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
  • Longo C; Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Int J Dermatol ; 59(7): 813-821, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32406113
ABSTRACT

BACKGROUND:

Nevus-associated melanoma (NAM) has been regarded as a distinct biological entity from de-novo melanoma (DNM); however, static dermoscopy often fails in differentiating these entities. Digital dermoscopic monitoring allows to identify dynamic changes occurring during follow-up; this may improve diagnostic accuracy and potentially our knowledge on NAM biology. We aimed to define main independent factors associated with NAM diagnosis and those influencing follow-up time in a population of melanomas excised at follow-up.

METHODS:

A cohort of melanomas excised at follow-up was retrospectively and consecutively selected. NAMs and DNMs were compared according to baseline features and main dermoscopic changes occurring during follow-up. Univariate and multivariable logistic and Cox's regression analysis were performed to respectively define factors associated with NAM diagnosis and those influencing the risk for excision.

RESULTS:

Eighty-six melanomas were enrolled, of which 21 (24.4%) were nevus-associated. During follow-up NAMs mainly underwent atypical network modifications (47.6%), followed by inverse network (28.6%) and dermoscopic island (23.8%) worsening or appearance. DNMs were also mainly characterized by atypical network modifications (47.7%), however, a significant proportion of cases underwent irregular pigmentation/dots/globules or regression changes (29.2%), which were rarely seen among NAMs. Furthermore, both multivariable logistic and Cox's regression analysis demonstrated a significant association between NAM and a longer follow-up.

CONCLUSIONS:

We demonstrated that among melanomas excised at follow-up, different patterns of dermoscopic changes may be found between NAMs and DNMs. This finding, together with the association of NAM with a longer follow-up time, supports the hypothesis of different biological behavior of these two entities.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Int J Dermatol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Itália