Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis.

Bürgi, Jérôme; Abrami, Laurence; Castanon, Irinka; Abriata, Luciano Andres; Kunz, Beatrice; Yan, Shixu Emili; Lera, Manuel; Unger, Sheila; Superti-Furga, Andrea; Peraro, Matteo Dal; Gaitan, Marcos Gonzalez; van der Goot, Francoise Gisou

Bürgi, Jérôme; Abrami, Laurence; Castanon, Irinka; Abriata, Luciano Andres; Kunz, Beatrice; Yan, Shixu Emili; Lera, Manuel; Unger, Sheila; Superti-Furga, Andrea; Peraro, Matteo Dal; Gaitan, Marcos Gonzalez; van der Goot, Francoise Gisou.

Afiliação

Bürgi J; Faculty of Life Sciences, Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; EMBL Hamburg DESY, 22607 Hamburg, Germany.
Abrami L; Faculty of Life Sciences, Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Castanon I; Departments of Biochemistry and of Molecular Biology, Sciences II, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
Abriata LA; Faculty of Life Sciences, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Kunz B; Faculty of Life Sciences, Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Yan SE; Faculty of Life Sciences, Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Lera M; Departments of Biochemistry and of Molecular Biology, Sciences II, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
Unger S; Division of Genetic Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
Superti-Furga A; Division of Genetic Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
Peraro MD; Faculty of Life Sciences, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Gaitan MG; Departments of Biochemistry and of Molecular Biology, Sciences II, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
van der Goot FG; Faculty of Life Sciences, Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address: gisou.vandergoot@epfl.ch.

Dev Cell ; 53(4): 418-430.e4, 2020 05 18.

Article em En | MEDLINE | ID: mdl-32428455

Assuntos

Colágeno Tipo VI/metabolismo; Endocitose; Síndrome da Fibromatose Hialina/patologia; Receptores de Colágeno/metabolismo; Receptores de Peptídeos/metabolismo; Talina/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Animais; Citoesqueleto/metabolismo; Feminino; Humanos; Síndrome da Fibromatose Hialina/genética; Síndrome da Fibromatose Hialina/metabolismo; Ligantes; Masculino; Mutação; Receptores de Colágeno/genética; Receptores de Peptídeos/genética; Talina/genética; Peixe-Zebra; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

GAPO syndrome; MYL12A; RhoA; Src; actin cytoskeleton; anthrax toxin receptor; collagen 6; extracellular matrix; hyaline fibromatosis syndrome; integrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talina / Receptores de Peptídeos / Proteína rhoA de Ligação ao GTP / Colágeno Tipo VI / Receptores de Colágeno / Endocitose / Síndrome da Fibromatose Hialina Limite: Animals / Female / Humans / Male Idioma: En Revista: Dev Cell Assunto da revista: EMBRIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos

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