Subgroup analysis of the early paracetamol trial to preterm infants found haemodynamic changes and improved oxygenation.
Early Hum Dev
; 145: 105042, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32442828
ABSTRACT
BACKGROUND:
We previously reported in a randomised trial that early intravenous paracetamol accelerated contraction of ductus arteriosus in very preterm infants (<32 gestation weeks).AIMS:
To monitor sequentially paracetamol effects on the blood pressure and brain tissue oxygenation in the infants participating the trial.METHODS:
In a double-blind trial, intravenous paracetamol or placebo was infused to 48 very premature infants starting within 24â¯h of birth for four days. Besides the ductus arteriosus, we systematically measured blood pressure, peripheral (spO2) and regional cerebral oxygen saturation (rcSO2), and cerebral fractional tissue oxygen extraction (cFTOE) during the study period.RESULTS:
Compared to the placebo, the paracetamol loading dose transiently decreased the arterial blood pressure. During treatment, the paracetamol-treated infants had higher spO2 (pâ¯=â¯.042) and rcSO2 (pâ¯=â¯.036) values than the placebo group infants. Additionally, the cFTOE values were lower in the paracetamol group during the study without statistical significance. All infants with closed ductus had higher tissue oxygenation and a lower cFTOE than infants with open ductus.CONCLUSIONS:
Paracetamol caused modest haemodynamic effects and increased cerebral oxygenation. They were mostly due to early contraction of ductus. Additional direct drug-effects in brain are not ruled-out.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Pressão Sanguínea
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Recém-Nascido Prematuro
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Analgésicos não Narcóticos
/
Acetaminofen
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
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Male
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Newborn
Idioma:
En
Revista:
Early Hum Dev
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Finlândia