cAblmediated tyrosine phosphorylation of DNA damage response proteins and implications in important cellular functions (Review).
Mol Med Rep
; 22(2): 612-619, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32468042
ABSTRACT
Tyrosine phosphorylation is an essential posttranslational protein modification catalyzed by tyrosine kinases. cAbl is a crucial nonreceptor tyrosine kinase, which is most commonly activated by autophosphorylation, DNA damage and by interacting with other protein kinases. DNA damage response (DDR) proteins stimulated by DNA lesions or chromatin alterations recruit the DNA repair and cell cycle checkpoint machinery to restore genome integrity and cellular homeostasis. The fundamental roles of activated cAbl tyrosine kinase in cellular response pathways have been intensively and extensively investigated and in recent years, a number of cAbl protein binding partners have been determined; however, the functional roles of these molecules remain to be determined. The present review aimed to summarize the DDR proteins phosphorylated by cAbl tyrosine kinase that have been identified to date, in addition to the functional outcomes of these phosphotyrosine events. Notably, it has been discovered that cAbl tyrosine kinase can bind with and phosphorylate DDR proteins at different tyrosine sites, which serve distinct roles in various cellular contexts.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilação
/
Tirosina
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Dano ao DNA
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Proteínas
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Proteínas Proto-Oncogênicas c-abl
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2020
Tipo de documento:
Article