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Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells.
Manzo, Teresa; Prentice, Boone M; Anderson, Kristin G; Raman, Ayush; Schalck, Aislyn; Codreanu, Gabriela S; Nava Lauson, Carina B; Tiberti, Silvia; Raimondi, Andrea; Jones, Marissa A; Reyzer, Michelle; Bates, Breanna M; Spraggins, Jeffrey M; Patterson, Nathan H; McLean, John A; Rai, Kunal; Tacchetti, Carlo; Tucci, Sara; Wargo, Jennifer A; Rodighiero, Simona; Clise-Dwyer, Karen; Sherrod, Stacy D; Kim, Michael; Navin, Nicholas E; Caprioli, Richard M; Greenberg, Philip D; Draetta, Giulio; Nezi, Luigi.
Afiliação
  • Manzo T; Department of Experimental Oncology, IRCCS European Institute of Oncology, Milano, Italy.
  • Prentice BM; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Anderson KG; Department of Biochemistry, Mass Spectrometry Research Center, Department of Chemistry, Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN.
  • Raman A; Clinical Research Division and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Schalck A; Departments of Medicine/Oncology and Immunology, University of Washington School of Medicine, Seattle, WA.
  • Codreanu GS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Nava Lauson CB; Department of Genetics and Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Tiberti S; Center for Innovative Technology, Vanderbilt University, Nashville, TN.
  • Raimondi A; Department of Experimental Oncology, IRCCS European Institute of Oncology, Milano, Italy.
  • Jones MA; Department of Experimental Oncology, IRCCS European Institute of Oncology, Milano, Italy.
  • Reyzer M; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, San Raffaele Vita-Salute University, Milano, Italy.
  • Bates BM; Department of Biochemistry, Mass Spectrometry Research Center, Department of Chemistry, Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN.
  • Spraggins JM; Department of Biochemistry, Mass Spectrometry Research Center, Department of Chemistry, Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN.
  • Patterson NH; Clinical Research Division and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • McLean JA; Departments of Medicine/Oncology and Immunology, University of Washington School of Medicine, Seattle, WA.
  • Rai K; Department of Biochemistry, Mass Spectrometry Research Center, Department of Chemistry, Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN.
  • Tacchetti C; Department of Biochemistry, Mass Spectrometry Research Center, Department of Chemistry, Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN.
  • Tucci S; Center for Innovative Technology, Vanderbilt University, Nashville, TN.
  • Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Rodighiero S; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, San Raffaele Vita-Salute University, Milano, Italy.
  • Clise-Dwyer K; Laboratory of Clinical Biochemistry and Metabolism Center for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.
  • Sherrod SD; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Kim M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Navin NE; Department of Experimental Oncology, IRCCS European Institute of Oncology, Milano, Italy.
  • Caprioli RM; Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Greenberg PD; Center for Innovative Technology, Vanderbilt University, Nashville, TN.
  • Draetta G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Nezi L; Department of Genetics and Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.
J Exp Med ; 217(8)2020 08 03.
Article em En | MEDLINE | ID: mdl-32491160
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Neoplasias Pancreáticas / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Carcinoma Ductal Pancreático / Ácidos Graxos / Microambiente Tumoral Limite: Animals Idioma: En Revista: J Exp Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Neoplasias Pancreáticas / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Carcinoma Ductal Pancreático / Ácidos Graxos / Microambiente Tumoral Limite: Animals Idioma: En Revista: J Exp Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália País de publicação: Estados Unidos