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Comparison of the gut microbiome composition among individuals with acute or long-standing spinal cord injury vs. able-bodied controls.
Li, Jia; Van Der Pol, William; Eraslan, Mualla; McLain, Amie; Cetin, Hatice; Cetin, Baris; Morrow, Casey; Carson, Tiffany; Yarar-Fisher, Ceren.
Afiliação
  • Li J; Departments of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Aabama.
  • Van Der Pol W; Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, Aabama.
  • Eraslan M; Departments of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Aabama.
  • McLain A; Departments of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Aabama.
  • Cetin H; Department of Physiotherapy and Rehabilitation, Hacettepe University, Turkey.
  • Cetin B; Department of Physiotherapy and Rehabilitation, Hacettepe University, Turkey.
  • Morrow C; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Aabama.
  • Carson T; Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Aabama.
  • Yarar-Fisher C; Departments of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Aabama.
J Spinal Cord Med ; 45(1): 91-99, 2022 01.
Article em En | MEDLINE | ID: mdl-32496944
Objective: Compare the gut microbiome composition among individuals with acute spinal cord injury (A-SCI), long-standing SCI (L-SCI), vs. able-bodied (AB) controls.Design: Cross-sectional study.Setting: The University of Alabama at Birmingham.Participants: Seven adults with A-SCI (36 ± 12 years, 2F/5M, C4-T10, and American Spinal Injury Association Impairment Scale [AIS] A-D), 25 with L-SCI (46 ± 13 years, 6F/19M, C4-L1, and AIS A-D), and 25 AB controls (42 ± 13 years, 9F/16M).Methods: Stool samples were collected after a median of 7 days and 18 years after injury in the A-SCI and L-SCI groups, respectively. Gut microbiome composition was analyzed using the 16S rRNA sequencing technique and QIIME software. The abundances of bacteria communities among groups were compared using the Kruskal-Wallis test adjusted for age.Results: Several alpha diversity indices were different among groups (Chao1, Observed species, and Phylogenetic Diversity), but not others (Shannon and Simpson). Beta diversity differed among each pair of groups (P < 0.05). A number of microbial communities were differentially abundant among the groups (P < 0.05).Conclusion: Our results revealed differences in the gut microbiome composition among groups. Compared to the AB controls, the SCI groups demonstrated microbiome profiles that shared features linked to metabolic syndrome, inflammation-related bowel disorders, depressive disorders, or antibiotics use, whereas the L-SCI group's microbiome included features linked to reduced physical activity compared to the A-SCI and AB controls. Our results provided preliminary data and a scientific foundation for future studies investigating the impact of the gut microbiome composition on long-term health in individuals with SCI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Microbioma Gastrointestinal Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: J Spinal Cord Med Assunto da revista: NEUROLOGIA / REABILITACAO Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Microbioma Gastrointestinal Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: J Spinal Cord Med Assunto da revista: NEUROLOGIA / REABILITACAO Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido